With increasing evidence that microbes colonize tumors, synthetic biology tools are being
leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered …

Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …

Bacterial biohybrids, composed of self-propelling bacteria carrying micro/nanoscale
materials, can deliver their payload to specific regions under magnetic control, enabling …

Pore-forming Gasdermin protein-induced pyroptosis in tumor cells promotes anti-tumor
immune response through the release of pro-inflammatory cytokines and immunogenic …

The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …

A major challenge facing tumor-antigen targeting therapies such as chimeric antigen
receptor (CAR)–T cells is the identification of suitable targets that are specifically and …

The use of living bacteria either as therapeutic agents or drug carriers has shown great
potential in treating a multitude of intractable diseases. However, cells are often fragile to …

Transient molecules in the gastrointestinal tract such as nitric oxide and hydrogen sulfide
are key signals and mediators of inflammation. Owing to their highly reactive nature and …

Adoptive cell therapy has emerged as a promising approach for cancer treatment. However,
the transfer of macrophages exhibits limited efficacy against solid tumors due to the dynamic …

Methods capable of manipulating bacterial colonization are of great significance for
modulating host-microbiota relationships. Here, we describe a strategy of in-situ chemical …