Ever since the discovery of the hypotensive and bradycardiac effects of adenosine,
adenosine receptors continue to represent promising drug targets. First, this is due to the fact …

The cystic fibrosis transmembrane conductance regulator (CFTR) is the product of the gene
mutated in patients with cystic fibrosis (CF). CFTR is a cAMP-regulated chloride channel …

Extracellular adenosine is a ubiquitous signaling molecule that modulates a wide array of
biological processes. Recently, significant advances have been made in our understanding …

Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and
interstitial lung disease are characterized by inflammation and tissue remodeling processes …

Given the widespread importance of purinergic receptor-evoked signaling, understanding
how ATP and other nucleotides are released from cells in a regulated manner is an …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated
chloride channel localized primarily at the apical or luminal surfaces of epithelial cells that …

β2-adrenergic receptors are present throughout the lung, including the alveolar airspace,
where they play an important role for regulation of the active Na+ transport needed for …

Nucleotides and nucleosides within the airway surface liquid regulate mucociliary clearance
(MCC) activities, the primary innate defense mechanism that removes foreign particles and …

Identification of a G protein-coupled receptor activated by UDP-glucose led us to develop a
sensitive and specific assay for UDP-glucose mass and to test whether this sugar nucleotide …

The tracheobronchial submucosal glands secrete liquid that is important for hydrating airway
surfaces, supporting mucociliary transport, and serving as a fluid matrix for numerous …