Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through
both cAMP-and Ca2+-dependent regulation of ion and water transport. In cystic fibrosis (CF) …

Recent progress in our understanding of the unique role of A 2B receptors in the regulation
of inflammation, immunity, and tissue repair was considerably facilitated with the introduction …

The cystic fibrosis transmembrane conductance regulator (CFTR) mutation ΔF508CFTR still
causes regulatory defects when rescued to the apical membrane, suggesting that the …

BACKGROUND & SIGNIFICANCE: The A2B adenosine receptor (A2BAR) is the
predominant adenosine receptor expressed in the colonic epithelia. We have previously …

We demonstrated previously that Calu-3 airway epithelial cells sense adenosine on their
luminal surface through adenosine A2B receptors coupled to adenylyl cyclase. Occupancy …

Adenosine is a signaling nucleoside that has been proposed to contribute to the
pathogenesis of asthma and chronic obstructive pulmonary disease. Previous studies …

The cystic fibrosis transmembrane conductance regulator CFTR gene is found on
chromosome 7 [Kerem, B., Rommens, JM, Buchanan, JA, Markiewicz, D., Cox, TK …

Purinergic receptors are a family of ubiquitous transmembrane receptors comprising two
classes, P1 and P2 receptors, which are activated by adenosine and extracellular …

Stimulation of purinergic receptors inhibits amiloride‐sensitive Na+ transport in epithelial
tissues by an unknown mechanism. Because previous studies excluded the role of …

We are testing the hypothesis that the malfunctioning of airway gland serous cells is a
component of cystic fibrosis (CF) airway disease. CF is caused by mutations that disrupt CF …