The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP and protein
kinase A (PKA)-regulated Cl–channel in the apical membrane of epithelial cells. The …

As the product of the gene mutated in cystic fibrosis, the most common genetic disease of
Caucasians, CFTR is an atypical ABC protein. From an evolutionary perspective, it is …

The pathophysiological processes underlying respiratory diseases like asthma are complex,
resulting in an overwhelming choice of potential targets for the novel treatment of this …

Melatonin and its analog 5-MCA-NAT (5-methylcarboxyamino-N-acetyl tryptamine) are
active compounds reducing intraocular pressure (IOP). This action is mediated through MT2 …

According to previous reports, flavonoids and nutraceuticals correct defective electrolyte
transport in cystic fibrosis (CF) airways. Traditional medicinal plants from China and …

High levels of chenodeoxycholic acid (CDCA) and deoxycholic acid stimulate Cl− secretion
in mammalian colonic epithelia. While different second messengers have been implicated in …

UTP‐induced chloride secretion by the intestinal mucosa mounted in Ussing chambers was
assessed by measurement of the short‐circuit current (Isc) in the presence of phloridzin in …

Adenosine, a signaling nucleoside, exhibits tissue-protective and tissue-destructive effects.
Adenosine levels in tissues are controlled in part by the enzyme adenosine deaminase …

Purinergic receptor stimulation has potential therapeutic effects for cystic fibrosis (CF). Thus,
we explored roles for P2Y and P2X receptors in stably increasing [Ca 2+] i in human CF (IB3 …

Preciseness of cellular behavior depends upon how an extracellular cue mobilizes a correct
orchestra of cellular messengers and effector proteins spatially and temporally. This …