Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

The prodrug concept has been used to improve undesirable properties of drugs since the
late 19th century, although it was only at the end of the 1950s that the actual term prodrug …

Most ocular diseases are treated by topical drug application in the form of aqueous eye drop
solutions. Recent studies have shown that cyclodextrins are useful additives in ophthalmic …

Written by experts in the field, this comprehensive resource offers valuable information on
the practical uses of drugs in primary eye care. Discussions of the pharmacology of ocular …

BACKGROUND: Much experience has been gained with the use of older classes of
antiglaucoma agents—topical beta-adrenergic-receptor antagonists, nonselective …

Importance of the field: Brimonidine is a drug used in the management of glaucoma
throughout the world and is the most modern α2-adrenoceptor agonist available. This review …

Most ocular diseases are treated by topical application of eyedrops. After instillation of an
eyedrop, typically less than 5% of the applied dose reaches the intraocular tissues. The low …

Glaucoma is the leading cause of blindness in the United States. It is estimated that two
million Americans have glaucoma and that the incidence of the disease in individuals aged …

• Every 12 hours 0.1% dipivefrin was administered to one eye and 2% epinephrine
hydrochloride was administered to the fellow eye of 42 patients with primary open-angle …

Adrenaline is a sympathomimetic drug used to maintain pupil dilation and to decrease the
risk of bleeding. The aim of this study was to demonstrate if adrenaline could exert …