Cancer-associated fibroblasts: epigenetic regulation and therapeutic intervention in breast cancer
Simple Summary Drug resistance and insensitivity to treatments are the main challenges in
breast cancer therapy. Cancer-associated fibroblasts (CAFs) are heterogeneous stromal …
breast cancer therapy. Cancer-associated fibroblasts (CAFs) are heterogeneous stromal …
Epigenetic regulation of cancer-associated fibroblast heterogeneity
RJ Kehrberg, N Bhyravbhatla, SK Batra… - Biochimica et Biophysica …, 2023 - Elsevier
Abstract Cancer-associated fibroblasts (CAFs), a significant component of the tumor
microenvironment (TME), contribute to cancer progression through the secretion of …
microenvironment (TME), contribute to cancer progression through the secretion of …
[HTML][HTML] Deconstructing tumor heterogeneity: the stromal perspective
Significant advances have been made towards understanding the role of immune cell-tumor
interplay in either suppressing or promoting tumor growth, progression, and recurrence …
interplay in either suppressing or promoting tumor growth, progression, and recurrence …
Cancer-associated fibroblasts: implications for cancer therapy
A Maia, S Wiemann - Cancers, 2021 - mdpi.com
Simple Summary Cancer-associated fibroblasts are important players of the tumour
microenvironment. They influence numerous processes during tumour development and …
microenvironment. They influence numerous processes during tumour development and …
Metallic nanoparticle-mediated immune cell regulation and advanced cancer immunotherapy
A Mohapatra, P Sathiyamoorthy, IK Park - Pharmaceutics, 2021 - mdpi.com
Cancer immunotherapy strategies leveraging the body's own immune system against cancer
cells have gained significant attention due to their remarkable therapeutic efficacy. Several …
cells have gained significant attention due to their remarkable therapeutic efficacy. Several …
Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts
Reciprocal interactions between cancer cells and stromal cells in the tumor
microenvironment (TME) are essential for full‐blown tumor development. Carcinoma …
microenvironment (TME) are essential for full‐blown tumor development. Carcinoma …
[HTML][HTML] Cancer-associated fibroblasts: Just on the opposite side of antitumour immunity?
S Guo, J Yuan, X Meng, X Feng, D Ma, Y Han… - International …, 2023 - Elsevier
The tumour microenvironment (TME) is critical for the initiation, progression, and metastasis
of tumours, and cancer-associated fibroblasts (CAFs) are the most dominant cells and have …
of tumours, and cancer-associated fibroblasts (CAFs) are the most dominant cells and have …
Spatial Transcriptomic and Metabolomic Landscapes of Oral Submucous Fibrosis‐Derived Oral Squamous Cell Carcinoma and its Tumor Microenvironment
Y Zhi, Q Wang, M Zi, S Zhang, J Ge, K Liu… - Advanced …, 2024 - Wiley Online Library
Abstract In South and Southeast Asia, the habit of chewing betel nuts is prevalent, which
leads to oral submucous fibrosis (OSF). OSF is a well‐established precancerous lesion, and …
leads to oral submucous fibrosis (OSF). OSF is a well‐established precancerous lesion, and …
A bird's eye view of fibroblast heterogeneity: a pan‐disease, pan‐cancer perspective
RN Pradhan, AT Krishnamurty… - Immunological …, 2021 - Wiley Online Library
Fibroblasts, custodians of tissue architecture and function, are no longer considered a
monolithic entity across tissues and disease indications. Recent advances in single‐cell …
monolithic entity across tissues and disease indications. Recent advances in single‐cell …
The heterogeneity of the tumor microenvironment as essential determinant of development, progression and therapy response of pancreatic cancer
Group Young Researchers in Inflammatory … - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is still one of the deadliest
cancers in western countries. It is commonly diagnosed at advanced stages and most anti …
cancers in western countries. It is commonly diagnosed at advanced stages and most anti …