Simple Summary Podoplanin (PDPN), also known as T1α/Aggrus/gp36, is a type I
transmembrane sialo-glycoprotein that plays essential roles in cancer progression and …

Tumor development and progression hinge upon ongoing coevolution and crosstalk with the
tumor microenvironment. In particular, fibroblasts in the tumor stroma are coopted to support …

Background & Aims Improving clinical management of early stage colorectal cancers
(T1CRCs) requires a better understanding of their underlying biology. Accumulating …

Breast cancer is the second leading cause of death among women worldwide, and while
hormone receptor positive subtypes have a clear and effective treatment strategy, other …

Simple Summary Bone metastasis is frequently complicated in patients with advanced solid
cancers such as breast, prostate and lung cancers, and impairs their prognosis. Bone …

Over the past decades, luminal epithelial cell lineage has gained considerable attraction as
the functionally milk-secreting units and as the most fruitful acreage for breast cancer …

Simple Summary This review summarises the current understanding of cancer-associated
fibroblasts (CAFs) in pancreatic ductal adenocarcinoma (PDAC). The aim of this review is to …

Cancer-associated fibroblasts (CAFs) are abundant and heterogeneous in tumor
microenvironment (TME). Cross-talk between cancer cells and CAFs results in cancer …

Activated fibroblasts, namely cancer-associated fibroblasts (CAFs), are highly
heterogeneous in phenotypes, functions, and origins. CAFs originated from varieties of cell …

Presentation of tumor antigens is a critical step in producing a robust antitumor immune
response. Classically tumor antigens are thought to be presented to both CD8 and CD4 T …