[HTML][HTML] Trailblazing perspectives on targeting breast cancer stem cells
Breast cancer (BCa) is one of the most prevalent malignant tumors affecting women's health
worldwide. The recurrence and metastasis of BCa have made it a long-standing challenge …
worldwide. The recurrence and metastasis of BCa have made it a long-standing challenge …
[HTML][HTML] Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses
Y Lan, TL Yeung, H Huang, AA Wegener… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Bintrafusp alfa (BA) is a bifunctional fusion protein designed for colocalized,
simultaneous inhibition of two immunosuppressive pathways, transforming growth factor-β …
simultaneous inhibition of two immunosuppressive pathways, transforming growth factor-β …
Single-cell transcriptome analysis of epithelial, immune, and stromal signatures and interactions in human ovarian cancer
C Chai, L Liang, NS Mikkelsen, W Wang… - Communications …, 2024 - nature.com
A comprehensive investigation of ovarian cancer (OC) progression at the single-cell level is
crucial for enhancing our understanding of the disease, as well as for the development of …
crucial for enhancing our understanding of the disease, as well as for the development of …
Roadmap on plasticity and epigenetics in cancer
The role of plasticity and epigenetics in shaping cancer evolution and response to therapy
has taken center stage with recent technological advances including single cell sequencing …
has taken center stage with recent technological advances including single cell sequencing …
Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer
Abstract Background Cancer-associated fibroblasts (CAFs) comprise a heterogeneous
population of stromal cells within the tumour microenvironment. CAFs exhibit both tumour …
population of stromal cells within the tumour microenvironment. CAFs exhibit both tumour …
Fibroblast heterogeneity in prostate carcinogenesis
Our understanding of stromal components, specifically cancer-associated fibroblasts (CAF),
in prostate cancer (PCa), has evolved from considering these cells as inert bystanders to …
in prostate cancer (PCa), has evolved from considering these cells as inert bystanders to …
[HTML][HTML] What's in a name? An emerging framework for cancer-associated fibroblasts, myofibroblasts, and fibroblasts
S Hasan, MB Buechler - Cancer Cell, 2022 - cell.com
In this issue of Cancer Cell, Foster and colleagues explore the heterogeneity in cancer-
associated fibroblasts (CAFs) across tissue types and species, and they identify …
associated fibroblasts (CAFs) across tissue types and species, and they identify …
The molecular classification of cancer‐associated fibroblasts on a pan‐cancer single‐cell transcriptional atlas
Abstract Background Cancer‐associated fibroblasts (CAFs), integral to the tumour
microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or …
microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic or …
[HTML][HTML] In vitro throughput screening of anticancer drugs using patient-derived cell lines cultured on vascularized three-dimensional stromal tissues
Y Takahashi, R Morimura, K Tsukamoto, S Gomi… - Acta Biomaterialia, 2024 - Elsevier
The development of high-throughput anticancer drug screening methods using patient-
derived cancer cell (PDC) lines that maintain their original characteristics in an in vitro three …
derived cancer cell (PDC) lines that maintain their original characteristics in an in vitro three …
AI powered quantification of nuclear morphology in cancers enables prediction of genome instability and prognosis
While alterations in nucleus size, shape, and color are ubiquitous in cancer, comprehensive
quantification of nuclear morphology across a whole-slide histologic image remains a …
quantification of nuclear morphology across a whole-slide histologic image remains a …