A variety of pharmacologically active substances, including chemotherapeutic drugs and the
substances from traditional Chinese medicine (TCM), always exhibit potent bioactivities after …

Leishmaniasis is a prevalent parasitic infection belonging to neglected tropical diseases. It is
caused by Leishmania protozoan parasites transmitted by sandflies and it is responsible for …

Supercritical CO 2 extraction of sucupira branca (SB) seeds was studied under different
conditions of pressure (20–40 MPa) and temperature (40 and 60° C). Operational conditions …

Cutaneous leishmaniasis (CL) is a neglected tropical skin disease caused by the protozoan
genus Leishmania. The treatment is restricted to a handful number of drugs that exhibit toxic …

In the last few decades, utilization of medicinal plants by the pharmaceutical industry has led
to the identification of many new bioactive compounds. The genus Pterodon, native of the …

The present work proposed a two-step sequential scCO 2 extraction process to selectively
extract the main bioactive compounds from annatto seeds, geranylgeraniol and tocols …

There is growing interest in the use of topical delivery systems that can modify the
permeation of drugs through the skin. Transdermal carriers containing hyaluronic acid have …

This systematic review investigated the evidence for the therapeutic potential of essential
oils (EOs) against Leishmania amazonensis. We searched available scientific publications …

Leishmania is a trypanosomatid that causes leishmaniasis. It is transmitted to vertebrate
hosts during the blood meal of phlebotomine sandflies. The clinical manifestations of the …

This study was conducted to optimize the supercritical carbon dioxide (scCO2) extraction of
oil from Gliricidia sepium seeds using response surface methodology. Initial experiments …