Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

Cancer-induced cachexia has a negative impact on quality of life and adversely affects
therapeutic outcomes and survival rates. It is characterized by, often severe, loss of muscle …

Background Cancer cachexia is a multifactorial debilitating syndrome that directly accounts
for more than 20% of cancer deaths while there is no effective therapeutic approach for …

Simple Summary Cancer cachexia is a multifactorial condition characterized by body weight
loss and skeletal muscle wasting that negatively impacts the quality of life and survival of …

Mice lacking the superoxide anion scavenger CuZn superoxide dismutase (Sod1−/− mice)
develop a number of age-related phenotypes, including an early progression of muscle …

Background Cancer immunotherapy has generated significant excitement, mainly as a result
of the development of immune checkpoint inhibitors. The blockade of PD-1 or its ligand with …

Scope Skeletal muscle atrophy is a critical feature of cancer‐associated cachexia (CAC) and
it is responsible for poor quality of life and high mortality in cancer patients. The previous …

Mitochondrial dysfunction is common to many organ system disorders, including skeletal
muscle. Aging muscle and diseases of muscle are often accompanied by defective …

Background Cancer cachexia is a cancer-induced multifactorial debilitating syndrome
directly accounting for 20% of cancer deaths without effective therapeutic approaches. It is …

Sarcopenia is an aging-related skeletal disease characterized by decreased muscle mass,
strength, and physical function, severely affecting the quality of life (QoL) of the elderly …