Directed evolution: methodologies and applications

Y Wang, P Xue, M Cao, T Yu, ST Lane… - Chemical reviews, 2021 - ACS Publications
Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production

YS Ko, JW Kim, JA Lee, T Han, GB Kim… - Chemical Society …, 2020 - pubs.rsc.org
Sustainable production of chemicals from renewable non-food biomass has become a
promising alternative to overcome environmental issues caused by our heavy dependence …

Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism

J Zhang, SD Petersen, T Radivojevic, A Ramirez… - Nature …, 2020 - nature.com
Through advanced mechanistic modeling and the generation of large high-quality datasets,
machine learning is becoming an integral part of understanding and engineering living …

Creative biological lignin conversion routes toward lignin valorization

ZH Liu, BZ Li, JS Yuan, YJ Yuan - Trends in Biotechnology, 2022 - cell.com
Lignin, the largest renewable aromatic resource, is a promising alternative feedstock for the
sustainable production of various chemicals, fuels, and materials. Despite this potential …

Adaptive laboratory evolution principles and applications in industrial biotechnology

M Mavrommati, A Daskalaki, S Papanikolaou… - Biotechnology …, 2022 - Elsevier
Adaptive laboratory evolution (ALE) is an innovative approach for the generation of evolved
microbial strains with desired characteristics, by implementing the rules of natural selection …

Metabolic engineering strategies to enable microbial utilization of C1 feedstocks

W Jiang, D Hernández Villamor, H Peng… - Nature Chemical …, 2021 - nature.com
Abstract One-carbon (C1) substrates are preferred feedstocks for the biomanufacturing
industry and have recently gained attention owing to their natural abundance, low …

Microbial foods for improving human and planetary health

LJ Jahn, VM Rekdal, MOA Sommer - Cell, 2023 - cell.com
The current food production system is negatively impacting planetary and human health. A
transition to a sustainable and fair food system is urgently needed. Microorganisms are likely …

Recent progress in genetically modified microalgae for enhanced carbon dioxide sequestration

B Barati, K Zeng, J Baeyens, S Wang, M Addy… - Biomass and …, 2021 - Elsevier
Reducing carbon dioxide (CO 2) emissions has been a hot research topic in recent years.
The integration of microalgae cultivation using CO 2 from power plants and factories has …