Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Based on its effects on both tumour cell intrinsic malignant properties as well as anti-tumour
immune responses, tryptophan catabolism has emerged as an important metabolic regulator …

Purpose The lack of effective molecular biomarkers to monitor idiopathic pulmonary fibrosis
(IPF) activity or treatment response remains an unmet clinical need. Herein, we determined …

Rationale: Sustained activation of lung fibroblasts and the resulting oversynthesis of the
extracellular matrix are detrimental events for patients with interstitial lung diseases (ILDs) …

Rationale α v integrins, key regulators of transforming growth factor-β activation and
fibrogenesis in in vivo models of pulmonary fibrosis, are expressed on abnormal epithelial …

Background Interstitial lung disease (ILD) is the most common cause of death in systemic
sclerosis. To date, the progression of systemic sclerosis-associated ILD is judged by the …

As the worldwide prevalence of chronic liver diseases is high and continuing to increase,
there is an urgent need for treatment to prevent cirrhosis‐related morbidity and mortality …

While the development of positron emission tomography (PET) radiopharmaceuticals
closely follows that of traditional drug development, there are several key considerations in …