Background The aim of the study was to assess the performance of the new Continuous
Mononuclear Cell Collection (CMNC) protocol on the Spectra Optia Apheresis System for …

An essential and influential first step in all cellular therapies is collecting donor or patient
cells. In hematopoietic progenitor cell transplantation, autologous or allogeneic …

BACKGROUND Peripheral blood stem cells (PBSCs) collected from granulocyte–colony‐
stimulating factor (G‐CSF)‐mobilized donors are routinely used for hematopoietic stem cell …

BACKGROUND Adoptive immunotherapy using engineered lymphocytes has shown
promising results in treating cancers even in patients who have failed other treatments. As …

Purpose We evaluated the Optia® continuous mononuclear collection (CMNC) system for
hematopoietic progenitor cell‐apheresis (HPC‐A) collection (Terumo BCT, Lakewood, CO) …

BACKGROUND Increased emphasis on cost and productivity in apheresis centers calls for a
proficient and predictable hematopoietic progenitor cell (HPC) collection. Therefore, the aim …

BACKGROUND Previous prediction algorithms to achieve target CD34+ goals have not
been widely adopted, with many centers still using a set volume to process for hematopoietic …

BACKGROUND The manufacturing of cellular products for immunotherapy, such as chimeric
antigen receptor T cells, requires successful collection of mononuclear cells. Collections …

BACKGROUND Autologous stem cell transplantation remains an integral treatment tool for
certain childhood malignancies. In children, a central venous catheter is typically necessary …

Therapeutic leukapheresis is a rapid and effective method to reduce early mortality of
patients with hyperleukocytic leukaemia (HLL). However, few studies on factors influencing …