Simple Summary IRS4 (insulin receptor substrate4) belongs to a family of intracellular
proteins that include IRS1 and IRS2 and whose physiological function is to transmit the …

Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene
expression by promoting large-scale transcriptional responses in various cell types and …

Simple Summary Transcription factors (TFs) can reprogram cellular states by modulating the
expression of their target genes and establishing gene expression programs under …

Enhancers are critical for regulating tissue-specific gene expression, and genetic variants
within enhancer regions have been suggested to contribute to various cancer-related …

Background This study targeted at developing a robust, prognostic signature based on
super-enhancer-related genes (SERGs) to reveal survival prognosis and immune …

Bone acts as a self-healing organ, which undergoes continuous regeneration process that is
tightly regulated by the cooperation of osteoclasts with the capability of bone resorption and …

Super-enhancers are a category of active super-enhancers densely occupied by
transcription factors and chromatin regulators, controlling the expression of disease-related …

Hypoxia and Ferroptosis are associated with the malignant behaviour of cervical cancer.
Endothelial PAS domain‐containing protein 1 (EPAS1) contributes to the progression of …

Background/Aim: Osteosarcoma at an advanced stage has a poor outcome, and novel
targeted therapies are needed, especially for metastatic disease. Bromodomain inhibitors …

Long non-coding RNA (lncRNA)− mediated control of gene expression contributes to
regulation of biological processes that include proliferation and phenotype, as well as …