Premature ovarian insufficiency (POI) is a heterogeneous disorder diagnosed in women
before 40 years old and describes a wide range of impaired ovarian function, from …

Primary ovarian insufficiency (POI) is a heterogeneous disease resulting from non-functional
ovaries in women before the age of 40. It is characterized by primary amenorrhea or …

Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction
characterized by cessation of menstruation occurring before the age of 40 years. The …

Purpose Premature ovarian insufficiency (POI) is a heterogeneous disorder characterized by
the cessation of menstrual cycles before the age of 40 years due to the depletion or …

Background: Gene set enrichment analysis (GSEA) was conducted on raw data, and
alternative splicing (AS) events were found after mRNA sequencing of human spermatozoa …

The diagnosis of primary ovarian insufficiency (POI) has untold effects on women and a
better understanding alongside potential treatments are paramount to improve quality of life …

Background The AARS2 gene encodes a mitochondrial alanyl-transfer RNA synthetase.
Defects in this gene have been linked with autosomal recessive inheritance of a variety of …

Premature ovarian insufficiency (POI) is one of the key aspects of ovarian infertility. Due to
early cession of ovarian function, POI imposes great challenges on the physiological and …

Objectives To report the first Mexican case with two novel AARS2 mutations causing primary
ovarian failure, uterus infantilis, and early-onset dementia secondary to …

Hypogonadotropic and hypergonadotropic forms of hypogonadism exist. In the
hypogonadotropic phenotype, functional etiology originates from GnRH neurons in the …