BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update
M Reig, A Forner, J Rimola, J Ferrer-Fàbrega… - Journal of …, 2022 - Elsevier
There have been major advances in the armamentarium for hepatocellular carcinoma
(HCC) since the last official update of the Barcelona Clinic Liver Cancer prognosis and …
(HCC) since the last official update of the Barcelona Clinic Liver Cancer prognosis and …
Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial
Background Single-agent nivolumab showed durable responses, manageable safety, and
promising survival in patients with advanced hepatocellular carcinoma in the phase 1–2 …
promising survival in patients with advanced hepatocellular carcinoma in the phase 1–2 …
Advances in immunotherapy for hepatocellular carcinoma
B Sangro, P Sarobe, S Hervás-Stubbs… - Nature reviews …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is a prevalent disease with a progression that is modulated
by the immune system. Systemic therapy is used in the advanced stage and until 2017 …
by the immune system. Systemic therapy is used in the advanced stage and until 2017 …
The immunological and metabolic landscape in primary and metastatic liver cancer
X Li, P Ramadori, D Pfister, M Seehawer… - Nature Reviews …, 2021 - nature.com
The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality and
has an increasing incidence worldwide. Locoregional therapies, defined as imaging-guided …
has an increasing incidence worldwide. Locoregional therapies, defined as imaging-guided …
Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal causes of cancer-
related death worldwide. The treatment of HCC remains challenging and is largely …
related death worldwide. The treatment of HCC remains challenging and is largely …
Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study
MS Lee, BY Ryoo, CH Hsu, K Numata, S Stein… - The Lancet …, 2020 - thelancet.com
Background Dual blockade of PD-L1 and VEGF has enhanced anticancer immunity through
multiple mechanisms and augmented antitumour activity in multiple malignancies. We …
multiple mechanisms and augmented antitumour activity in multiple malignancies. We …
Updated treatment recommendations for hepatocellular carcinoma (HCC) from the ESMO Clinical Practice Guidelines
A Vogel, E Martinelli, A Cervantes, I Chau… - Annals of …, 2021 - annalsofoncology.org
Sorafenib: sorafenib has only been evaluated in the firstline setting. Phase IV/observational
studies have not revealed new safety signals in patients with Childe Pugh B cirrhosis 4 [I, A; …
studies have not revealed new safety signals in patients with Childe Pugh B cirrhosis 4 [I, A; …
International trends in hepatocellular carcinoma incidence, 1978–2012
JL Petrick, AA Florio, A Znaor… - … journal of cancer, 2020 - Wiley Online Library
Primary liver cancer, the major histology of which is hepatocellular carcinoma (HCC), is the
second leading cause of cancer death worldwide. We comprehensively examined recent …
second leading cause of cancer death worldwide. We comprehensively examined recent …