Brain organoids created from human pluripotent stem cells represent a promising approach
for brain repair. They acquire many structural features of the brain and raise the possibility of …

Reprogramming brain-resident glial cells into clinically relevant induced neurons (iNs) is an
emerging strategy toward replacing lost neurons and restoring lost brain functions. A …

Brain organoids are three-dimensional neural aggregates derived from pluripotent stem
cells through self-organization and recapitulate architectural and cellular aspects of certain …

Stem cell therapy using human skin-derived neural precursors holds much promise for the
treatment of stroke patients. Two main mechanisms have been proposed to give rise to the …

How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …

Numerous studies have used human pluripotent stem cell-derived cerebral organoids to
elucidate the mystery of human brain development and model neurological diseases in vitro …

Stroke is the second leading cause of death and main cause of disability worldwide, but with
few effective therapies. Although stem cell-based therapy has been proposed as an exciting …

Microinjection protocols are ubiquitous throughout biomedical fields, with hollow
microneedle arrays (MNAs) offering distinctive benefits in both research and clinical settings …

Cell replacement is currently being explored as a therapeutic approach for
neurodegenerative disease. Using stem cells as a source, transplantable progenitors can …

The reconstruction of lost neural circuits by cell replacement is a possible treatment for
neurological deficits after cerebral cortex injury. Cerebral organoids can be a novel source …