[图书][B] Characterising the impact of obesity on Dendritic Cell metabolism & function

ADT Woodcock - 2023 - search.proquest.com
Obesity is a worldwide epidemic, as of 2016, over 650 million people were living with
obesity. Obesity is strongly associated with over 200 comorbidities. In addition, people with …

INVESTIGATING CELLULAR INNATE IMMUNE RESPONSES TO INTESTINAL YERSINIA INFECTION

J Zhang - 2023 - repository.upenn.edu
Enteric pathogens make up a large global burden of disease, causing gastrointestinal
disease in human hosts. The Gram-negative bacterial pathogen Yersinia …

Human TLR4 and noncanonical inflammasome differ in their ability to respond to distinct lipid A variants

J Alexander-Floyd, AR Bass, EM Harberts, D Grubaugh… - bioRxiv, 2021 - biorxiv.org
Detection of Gram-negative bacterial lipid A by the extracellular sensor, MD-2/TLR4 or the
intracellular inflammasome sensors, CASP4 and CASP5, induces robust inflammatory …

Structural and Functional Determinants of Caspase-11 Inflammasome Assembly during Innate Immune Defense

DC Akuma - 2022 - search.proquest.com
Abstract Caspase-11 (Casp11) is a pattern-recognition receptor that senses cytosolic LPS.
In response to binding cytosolic LPS, Casp11 assembles into a supramolecular organizing …