BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …

Chronic kidney disease (CKD) is characterized by increased levels of oxidative stress and
inflammation. Oxidative stress and inflammation promote renal injury via damage to …

The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …

Arabidopsis thaliana is a long established model species for plant molecular biology,
genetics and genomics, and studies of A. thaliana gene function provide the basis for …

Gene functional descriptions offer a crucial line of evidence for candidate genes underlying
trait variation. Conversely, plant responses to environmental cues represent important …

RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …

Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Using deep
RNA profiling in different mouse tissues, we observed that circRNAs were substantially …

We present primary results from the Sequencing Quality Control (SEQC) project,
coordinated by the US Food and Drug Administration. Examining Illumina HiSeq, Life …

For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …