A pig BodyMap transcriptome reveals diverse tissue physiologies and evolutionary dynamics of transcription
A comprehensive transcriptomic survey of pigs can provide a mechanistic understanding of
tissue specialization processes underlying economically valuable traits and accelerate their …
tissue specialization processes underlying economically valuable traits and accelerate their …
TISSUES 2.0: an integrative web resource on mammalian tissue expression
Physiological and molecular similarities between organisms make it possible to translate
findings from simpler experimental systems—model organisms—into more complex ones …
findings from simpler experimental systems—model organisms—into more complex ones …
Age-related gene expression signature in rats demonstrate early, late, and linear transcriptional changes from multiple tissues
To understand the changes in gene expression that occur as a result of age, which might
create a permissive or causal environment for age-related diseases, we produce a multi …
create a permissive or causal environment for age-related diseases, we produce a multi …
MARRVEL: integration of human and model organism genetic resources to facilitate functional annotation of the human genome
One major challenge encountered with interpreting human genetic variants is the limited
understanding of the functional impact of genetic alterations on biological processes …
understanding of the functional impact of genetic alterations on biological processes …
Growing old, yet staying young: the role of telomeres in bats' exceptional longevity
Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …
A comprehensive mouse transcriptomic BodyMap across 17 tissues by RNA-seq
The mouse has been widely used as a model organism for studying human diseases and for
evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity …
evaluating drug safety and efficacy. Many diseases and drug effects exhibit tissue specificity …
Neurobiology and therapeutic potential of α5-GABA type A receptors
TC Jacob - Frontiers in molecular neuroscience, 2019 - frontiersin.org
α5 subunit containing GABA type A receptors (GABAARs) have long been an enigmatic
receptor subtype of interest due to their specific brain distribution, unusual surface …
receptor subtype of interest due to their specific brain distribution, unusual surface …
HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models
E Benito, H Urbanke, B Ramachandran… - The Journal of …, 2015 - Am Soc Clin Investig
Aging and increased amyloid burden are major risk factors for cognitive diseases such as
Alzheimer's disease (AD). Effective therapies for these diseases are lacking. Here, we …
Alzheimer's disease (AD). Effective therapies for these diseases are lacking. Here, we …
Atmospheric H2S triggers immune damage by activating the TLR-7/MyD88/NF-κB pathway and NLRP3 inflammasome in broiler thymus
X Hu, Q Chi, Q Liu, D Wang, Y Zhang, S Li - Chemosphere, 2019 - Elsevier
Atmospheric hydrogen sulfide (H 2 S) is a highly toxic air pollutant that has a negative effect
on human health and animal welfare. The immunotoxicity of H 2 S has been explored …
on human health and animal welfare. The immunotoxicity of H 2 S has been explored …
An RNA-Seq atlas of gene expression in mouse and rat normal tissues
Gene functionality is closely connected to its expression specificity across tissues and cell
types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim …
types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim …