Both being dormant cellular states, quiescence and senescence are traditionally considered
distinct. Quiescence is reversible to proliferation upon growth signals, whereas senescence …

Animal studies are required for the evaluation of candidate drugs to ensure patient and
volunteer safety. Toxicogenomics is often applied in these studies to gain understanding of …

Complementing genome sequence with deep transcriptome and proteome data could
enable more accurate assembly and annotation of newly sequenced genomes. Here, we …

Background Expression patterns between males and females vary in every adult tissue,
even in organs with no conspicuous dimorphisms such as the heart. While studies of male …

Planarians display remarkable plasticity in maintenance of their germline, with the ability to
develop or dismantle reproductive tissues in response to systemic and environmental cues …

Adipose tissues are phenotypically, metabolically and functionally heterogeneous based on
the sites of their deposition. Undesirable fat deposits in the body are often detrimental to …

Regulation of intracellular pH (pHi) in cardiomyocytes is crucial for cardiac function;
however, currently known mechanisms for direct or indirect extrusion of acid from …

Current experimental methods to identify the functions of a large number of the candidates of
long non-coding RNAs (lncRNAs) are limited in their throughput. Therefore, it is essential to …

Survivors of hypoxic-ischemic brain damage (HIBD), besides impairment of psychomotor
development, often develop circadian rhythm disorders, although the underlying …

Thioredoxin/glutathione reductase (TXNRD3) is a selenoprotein composed of thioredoxin
reductase and glutaredoxin domains. This NADPH-dependent thiol oxidoreductase evolved …