Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

Bone and bone marrow are among the most frequent metastatic sites of cancer. The
occurrence of bone metastasis is frequently associated with a dismal disease outcome. The …

A common stage of advanced prostate cancer is castration-resistant prostate cancer
(CRPC), greater understanding of which is required in order to address and solve the …

While meant for wound healing and immunity in response to injury and infection,
inflammatory signaling is usurped by cancerous tumors to promote disease progression …

Breast cancer is the most commonly diagnosed cancer in the USA. Although advances in
treatment over the past several decades have significantly improved the outlook for this …

Breast cancer bone metastasis is currently incurable,~ 75% of patients with late-stage breast
cancer develop disease recurrence in bone and available treatments are only palliative. We …

While numerous therapies are highly efficacious in early-stage breast cancers and in
particular subsets of breast cancers, therapeutic resistance and metastasis unfortunately …

Bone is the most common site for advanced breast cancer to metastasise. The
proinflammatory cytokine, interleukin-1β (IL-1β) plays a complex and contradictory role in …

Patients with advanced breast cancer are at high risk of developing bone metastasis.
Despite treatment advances for primary breast cancer, metastatic bone disease remains …

The most common site of metastasis in breast cancer is the bone, where the balance
between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is …