From targeted methods to metabolomics based strategies to screen for growth promoters misuse in horseracing and livestock: A review

C Cloteau, Z Kaabia, B Le Bizec, L Bailly-Chouriberry… - Food Control, 2023 - Elsevier
Despite banned for public health, societal and economic reasons, and therefore strictly
regulated, growth promoters can still be used in farm animals to increase production yields …

Doping detection in animals: A review of analytical methodologies published from 1990 to 2019

F Moreira, H Carmo, P Guedes de Pinho… - Drug Testing and …, 2021 - Wiley Online Library
Despite the impressive innate physical abilities of horses, camels, greyhounds, or pigeons,
doping agents might be administered to these animals to improve their performance. To …

[HTML][HTML] Investigations into the elimination profiles and metabolite ratios of micro-dosed selective androgen receptor modulator LGD-4033 for doping control purposes

F Wagener, S Guddat, C Görgens, YS Angelis… - Analytical and …, 2022 - Springer
Abstract LGD-4033 (ligandrol) is a selective androgen receptor modulator (SARM), which is
prohibited in sports by the World Anti-Doping Agency (WADA) and led to 62 adverse …

Identification of equine in vitro metabolites of seven non‐steroidal selective androgen receptor modulators for doping control purposes

C Cutler, M Viljanto, P Taylor, P Hincks… - Drug Testing and …, 2022 - Wiley Online Library
Selective androgen receptor modulators, SARMs, are a large class of compounds
developed to provide therapeutic anabolic effects with minimal androgenic side effects. A …

Detection of the selective androgen receptor modulator GSK2881078 and metabolites in urine and hair after single oral administration

A Rading, P Anielski, D Thieme… - Drug Testing and …, 2021 - Wiley Online Library
Hair and urine concentrations of the nonsteroidal selective androgen receptor modulator
GSK2881078 were examined following single oral administration to investigate its hair …

Long‐term monitoring of IOX4 in horse hair and its longitudinal distribution with segmental analysis using liquid chromatography/electrospray ionization Q Exactive …

H Ishii, M Shibuya, YM So, JKY Wong… - Drug Testing and …, 2022 - Wiley Online Library
IOX4, a hypoxia‐inducible factor stabilizer, is classified as a banned substance for horses in
both horse racing and equestrian sports. We recently reported the pharmacokinetic profiles …

[HTML][HTML] Structure revision and chemical synthesis of ligandrol's main bishydroxylated long-term metabolic marker

EN Pitsinos, YS Angelis, M Petrou - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
Although the main bishydroxylated long-term metabolite of the WADA-banned anabolic
agent ligandrol (LGD-4033) is an important metabolic marker, it is not readily available in …

[HTML][HTML] Investigations into the concentration and metabolite profiles of stanozolol and LGD-4033 in blood plasma and seminal fluid using liquid chromatography high …

J Breuer, A Thomas, P Delahaut, W Schänzer… - Analytical and …, 2023 - Springer
Potential scenarios as to the origin of minute amounts of banned substances detected in
doping control samples have been a much-discussed problem in anti-doping analysis in …

Metabolic studies of selective androgen receptor modulators RAD140 and S‐23 in horses

YM So, JKY Wong, TLS Choi, A Prabhu… - Drug Testing and …, 2021 - Wiley Online Library
This paper describes the studies of the in vitro biotransformation of two selective androgen
receptor modulators (SARMs), namely, RAD140 and S‐23, and the in vivo metabolism of …

Equine metabolism of the selective androgen receptor modulator YK‐11 in urine and plasma following oral administration

C Harding, M Viljanto… - Drug Testing and …, 2023 - Wiley Online Library
YK‐11 is a steroidal selective androgen receptor modulator, a compound class prohibited in
both equine racing and human sports because of their potentially performance enhancing …