With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

Mitochondria are attractive targets for novel molecules to limit IRI-associated inflammation.
Although dynamic preservation techniques could serve as delivery tool for new therapeutic …

Current machine perfusion technology permits livers to be preserved ex situ for short periods
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …

Normothermic machine perfusion (NMP) after static cold storage is increasingly used for
preservation and assessment of human donor livers prior to transplantation. Biliary viability …

Objective: To develop a protocol for the defatting of steatotic liver grafts during long-term ex
situ normothermic machine perfusion. Background: Despite the alarming increase in donor …

Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating
physiological conditions such as body temperature. Recent advancements in NMP system …

Liver allograft steatosis is a significant risk factor for postoperative graft dysfunction and has
been associated with inferior patient and graft survival, particularly in the case of moderate …

Ischemic heart failure (IHF) is a leading cause of morbidity and mortality worldwide, for
which heart transplantation remains the only definitive treatment. IHF manifests from …

Background: Liver transplantation is a lifesaving procedure for patients with end-stage liver
disease (ESLD). However, many patients never receive a transplant due to insufficient donor …

Sterile inflammation is the immune response to damage-associated molecular patterns
(DAMPs) released during cell death in the absence of foreign pathogens. In the setting of …