Adrenoceptor Desensitization: Current understanding of mechanisms
D Maaliki, AA Jaffa, S Nasser, A Sahebkar… - Pharmacological …, 2024 - ASPET
G-protein coupled receptors (GPCRs) transduce a wide range of extracellular signals. They
are key players in the majority of biologic functions including vision, olfaction, chemotaxis …
are key players in the majority of biologic functions including vision, olfaction, chemotaxis …
[HTML][HTML] The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis
Lung inflammatory disorders are a major global health burden, impacting millions of people
and raising rates of morbidity and death across many demographic groups. An industrial …
and raising rates of morbidity and death across many demographic groups. An industrial …
[HTML][HTML] The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome
Y Wang, C Zhu, P Li, Q Liu, H Li, C Yu, X Deng… - Frontiers in …, 2023 - frontiersin.org
Sepsis is defined as a life-threatening dysfunction due to a dysregulated host response to
infection. It is a common and complex syndrome and is the leading cause of death in …
infection. It is a common and complex syndrome and is the leading cause of death in …
[HTML][HTML] The role of P2Y6 receptor in the pathogenesis of cardiovascular and inflammatory diseases
K Nishiyama - Journal of Pharmacological Sciences, 2024 - Elsevier
The purinergic receptor P2Y 6 receptor (P2Y 6 R) is a member of the G protein-coupled
receptors (GPCR) family. P2Y 6 R is widely expressed in various cell types and plays a …
receptors (GPCR) family. P2Y 6 R is widely expressed in various cell types and plays a …
[HTML][HTML] Activation of hepatic acetyl-CoA carboxylase by S-nitrosylation in response to diet
NM Venetos, CT Stomberski, Z Qian, RT Premont… - Journal of Lipid …, 2024 - ASBMB
Nitric oxide (NO), produced primarily by nitric oxide synthase enzymes, is known to influence
energy metabolism by stimulating fat uptake and oxidation. The effects of NO on de novo …
energy metabolism by stimulating fat uptake and oxidation. The effects of NO on de novo …
[HTML][HTML] Reactive Oxygen Species Behaving Badly: Oxidized Phosphatidylcholines Corrupt Ca2+ Signaling in Airway Smooth Muscle
DA Deshpande, RB Penn - American Journal of Respiratory Cell …, 2023 - atsjournals.org
Increasing evidence points to oxidative stress affecting multiple cell types as an important
driver of obstructive lung diseases. Reactive oxygen and nitrogen species (ROS/RNS) …
driver of obstructive lung diseases. Reactive oxygen and nitrogen species (ROS/RNS) …
A cryptic mode of GPCR regulation revealed
DA Deshpande, RB Penn - Trends in Molecular Medicine, 2022 - cell.com
Over three decades of research have provided thorough insights into G protein-coupled
receptor (GPCR) regulation. In a recent issue of Molecular Cell, Fonseca et al. identified a …
receptor (GPCR) regulation. In a recent issue of Molecular Cell, Fonseca et al. identified a …
[HTML][HTML] Protocol for preparing Thiopropyl Sepharose resin used for capturing S-nitrosylated proteins
Summary S-nitrosothiol (SNO)-Resin Assisted Capture (SNO-RAC) relies on a Thiopropyl
Sepharose resin to identify S-nitrosylated proteins (SNO-proteins) and sites of S …
Sepharose resin to identify S-nitrosylated proteins (SNO-proteins) and sites of S …
Paradoxical bronchodilator response is associated with increased risk of asthma exacerbations
B Fakhry, C Chedraoui, J Sleiman, A Attaway… - The Journal of Allergy …, 2024 - Elsevier
Paradoxical bronchodilator-induced airway response (PBDR) is defined as the 35
unexpected constriction of smooth muscle-lined walls of the bronchi in response to a 36 …
unexpected constriction of smooth muscle-lined walls of the bronchi in response to a 36 …
The β2AR gets SNOed
JF Foley - Science Signaling, 2022 - science.org
The β2AR gets SNOed | Science Signaling news careers commentary Journals Science
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Science brought to you byGoogle Indexer Log in journal-menu-img science journal-menu-img …