Mammalian cell cycle cyclins
D Martínez-Alonso, M Malumbres - Seminars in cell & developmental …, 2020 - Elsevier
Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …
Genomic predictors of outcome in prostate cancer
Context Given the highly variable behavior and clinical course of prostate cancer (PCa) and
the multiple available treatment options, a personalized approach to oncologic risk …
the multiple available treatment options, a personalized approach to oncologic risk …
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
Prostate cancers remain indolent in the majority of individuals but behave aggressively in a
minority,. The molecular basis for this clinical heterogeneity remains incompletely …
minority,. The molecular basis for this clinical heterogeneity remains incompletely …
Discovery and validation of a prostate cancer genomic classifier that predicts early metastasis following radical prostatectomy
Purpose Clinicopathologic features and biochemical recurrence are sensitive, but not
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …
Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study
Background Optimum management of clinically localised prostate cancer presents unique
challenges because of the highly variable and often indolent natural history of the disease …
challenges because of the highly variable and often indolent natural history of the disease …
Associations of luminal and basal subtyping of prostate cancer with prognosis and response to androgen deprivation therapy
Importance There is a clear need for a molecular subtyping approach in prostate cancer to
identify clinically distinct subgroups that benefit from specific therapies. Objectives To …
identify clinically distinct subgroups that benefit from specific therapies. Objectives To …
RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1
Background Improved clinical predictors for disease progression are needed for localised
prostate cancer, since only a subset of patients develop recurrent or refractory disease after …
prostate cancer, since only a subset of patients develop recurrent or refractory disease after …
Development and validation of a 24-gene predictor of response to postoperative radiotherapy in prostate cancer: a matched, retrospective analysis
Background Postoperative radiotherapy has an important role in the treatment of prostate
cancer, but personalised patient selection could improve outcomes and spare unnecessary …
cancer, but personalised patient selection could improve outcomes and spare unnecessary …
Combined value of validated clinical and genomic risk stratification tools for predicting prostate cancer mortality in a high-risk prostatectomy cohort
Background Risk prediction models that incorporate biomarkers and clinicopathologic
variables may be used to improve decision making after radical prostatectomy (RP). We …
variables may be used to improve decision making after radical prostatectomy (RP). We …
Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII–p38MAPK–pS249/T252RB pathway
LY Yu-Lee, G Yu, YC Lee, SC Lin, J Pan, T Pan, KJ Yu… - Cancer research, 2018 - AACR
Bone metastasis from prostate cancer can occur years after prostatectomy, due to
reactivation of dormant disseminated tumor cells (DTC) in the bone, yet the mechanism by …
reactivation of dormant disseminated tumor cells (DTC) in the bone, yet the mechanism by …