Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendrite arbors, and dendritic …

Neurons are among the most highly polarized cell types in the body, and the polarization of
axon and dendrites underlies the ability of neurons to integrate and transmit information in …

Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …

Persistent symptoms of depression suggest the involvement of stable molecular adaptations
in brain, which may be reflected at the level of chromatin remodeling. We find that chronic …

Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric
disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 …

One of the most remarkable features of the developing brain is its ability to undergo
structural change in response to experience. Among the cellular elements that show this …

▪ Abstract The actin cytoskeleton plays a major role in morphological development of
neurons and in structural changes of adult neurons. This article reviews the myriad functions …

The molecular mechanisms that determine the size and complexity of the neuronal dendritic
tree are unclear. Here, we show that the phosphoinositide-3′ kinase (PI3K)–Akt …

The vertebrate retina is comprised of seven major cell types that are generated in
overlapping but well-defined intervals. To identify genes that might regulate retinal …

The Wnt signaling pathway plays a role in the development of the central nervous system
and growing evidence indicates that Wnts also regulates the structure and function of the …