Amyloidosis and the Kidney: An Update

R Nader, A Angel-Korman, A Havasi - Seminars in Nephrology, 2022 - Elsevier
Various types of systemic amyloidosis can wreak havoc on the architecture and functioning
of the kidneys. Amyloidosis should be suspected in patients with worsening kidney function …

The mechanism of action, pharmacological characteristics, and clinical utility of the amyloid depleter birtamimab for the potential treatment of AL amyloidosis

G Palladini, M Liedtke, W Zago, P Dolan… - Leukemia & …, 2024 - Taylor & Francis
Amyloid light chain (AL) amyloidosis is a progressive plasma cell disorder caused by
amyloid deposition resulting in organ damage and failure. Current standard-of-care …

Redesigning the kinetics of lysozyme amyloid aggregation by cephalosporin molecules

SA Muthu, A Qureshi, R Sharma, I Bisaria… - Journal of …, 2024 - Taylor & Francis
In lysozyme amyloidosis, fibrillar aggregates of lysozyme are associated with severe renal,
hepatic, and gastrointestinal manifestations, with no definite therapy. Current drugs are now …

Bad players in AL amyloidosis in the current era of treatment

N Kreiniz, MA Gertz - Expert review of hematology, 2023 - Taylor & Francis
ABSTRACT Introduction Systemic AL amyloidosis (ALA) is a clonal plasma cell (PC) disease
characterized by deposition of amyloid fibrils in different organs and tissues. Traditionally …

Structural investigation of Serum Amyloid A fibrils using solid-state NMR and the effect of Heparin on SAA aggregation

A Sundaria - 2023 - mediatum.ub.tum.de
This project uses solid-state NMR to investigate the structure of in vitro prepared Serum
Amyloid A (SAA) protein fibrils in bulk using extracted fibrils as seeds. A comparative …