Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment

SE Shore, LE Roberts, B Langguth - Nature Reviews Neurology, 2016 - nature.com
Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people
worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with …

[HTML][HTML] Central gain control in tinnitus and hyperacusis

BD Auerbach, PV Rodrigues, RJ Salvi - Frontiers in neurology, 2014 - frontiersin.org
Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural
activity transmitted from the cochlea to the central auditory system. Despite a reduced …

Ringing ears: the neuroscience of tinnitus

LE Roberts, JJ Eggermont, DM Caspary… - Journal of …, 2010 - Soc Neuroscience
Tinnitus is a phantom sound (ringing of the ears) that affects quality of life for millions around
the world and is associated in most cases with hearing impairment. This symposium will …

[HTML][HTML] Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis

M Knipper, P Van Dijk, I Nunes, L Rüttiger… - Progress in …, 2013 - Elsevier
The prevalence of hearing problems in the Western world has, due to aging of the
population, doubled over the past 30 years. Thereby, noise-induced hearing loss is an …

Underlying mechanisms of tinnitus: review and clinical implications

JA Henry, LE Roberts, DM Caspary… - Journal of the …, 2014 - thieme-connect.com
Background: The study of tinnitus mechanisms has increased tenfold in the last decade. The
common denominator for all of these studies is the goal of elucidating the underlying neural …

[PDF][PDF] Mechanisms of noise-induced tinnitus: insights from cellular studies

SE Shore, C Wu - Neuron, 2019 - cell.com
Tinnitus, sound perception in the absence of physical stimuli, occurs in 15% of the
population and is the top-reported disability for soldiers after combat. Noise overexposure is …

What's the buzz? The neuroscience and the treatment of tinnitus

A Henton, T Tzounopoulos - Physiological reviews, 2021 - journals.physiology.org
Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

Tinnitus: models and mechanisms

JA Kaltenbach - Hearing research, 2011 - Elsevier
Over the past decade, there has been a burgeoning of scientific interest in the
neurobiological origins of tinnitus. During this period, numerous behavioral and …

Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans

KL Marks, DT Martel, C Wu, GJ Basura… - Science Translational …, 2018 - science.org
The dorsal cochlear nucleus is the first site of multisensory convergence in mammalian
auditory pathways. Principal output neurons, the fusiform cells, integrate auditory nerve …

[HTML][HTML] Conformational transitions and allosteric modulation in a heteromeric glycine receptor

E Gibbs, E Klemm, D Seiferth, A Kumar, SL Ilca… - Nature …, 2023 - nature.com
Abstract Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and
brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs …