Inhibitory neurotransmission in animal models of tinnitus: maladaptive plasticity

H Wang, TJ Brozoski, DM Caspary - Hearing research, 2011 - Elsevier
Tinnitus is a phantom auditory sensation experienced by up to 14% of the United States
population with a smaller percentage experiencing decreased quality of life. A compelling …

Somatosensory tinnitus: Current evidence and future perspectives

M Ralli, A Greco, R Turchetta… - Journal of …, 2017 - journals.sagepub.com
In some individuals, tinnitus can be modulated by specific maneuvers of the
temporomandibular joint, head and neck, eyes, and limbs. Neuroplasticity seems to play a …

Tinnitus: maladaptive auditory–somatosensory plasticity

C Wu, RA Stefanescu, DT Martel, SE Shore - Hearing research, 2016 - Elsevier
Tinnitus, the phantom perception of sound, is physiologically characterized by an increase in
spontaneous neural activity in the central auditory system. However, as tinnitus is often …

Stimulus timing-dependent plasticity in dorsal cochlear nucleus is altered in tinnitus

SD Koehler, SE Shore - Journal of Neuroscience, 2013 - Soc Neuroscience
Tinnitus and cochlear damage have been associated with changes in somatosensory-
auditory integration and plasticity in the dorsal cochlear nucleus (DCN). Recently, we …

[HTML][HTML] Gap-prepulse inhibition of the acoustic startle reflex (GPIAS) for tinnitus assessment: current status and future directions

A Galazyuk, S Hébert - Frontiers in neurology, 2015 - frontiersin.org
The progress in the field of tinnitus largely depends on the development of a reliable tinnitus
animal model. Recently, a new method based on the acoustic startle reflex modification was …

[HTML][HTML] Development of tinnitus in CBA/CaJ mice following sound exposure

RJ Longenecker, AV Galazyuk - Journal of the Association for Research in …, 2011 - Springer
Tinnitus, the perception of a sound without an external acoustic source, is a complex
perceptual phenomenon affecting the quality of life in 17% of the adult population. Despite …

Glycine receptors and glycine transporters: targets for novel analgesics?

HU Zeilhofer, MA Acuña, J Gingras… - Cellular and Molecular …, 2018 - Springer
Glycinergic neurotransmission has long been known for its role in spinal motor control.
During the last two decades, additional functions have become increasingly recognized …

Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus

W Singer, A Zuccotti, M Jaumann, SC Lee… - Molecular …, 2013 - Springer
Increasing evidence shows that hearing loss is a risk factor for tinnitus and hyperacusis.
Although both often coincide, a causal relationship between tinnitus and hyperacusis has …

[HTML][HTML] Auditory thalamic circuits and GABAA receptor function: Putative mechanisms in tinnitus pathology

DM Caspary, DA Llano - Hearing research, 2017 - Elsevier
Tinnitus is defined as a phantom sound (ringing in the ears), and can significantly reduce the
quality of life for those who suffer its effects. Ten to fifteen percent of the general adult …

The gap-startle paradigm for tinnitus screening in animal models: limitations and optimization

E Lobarinas, SH Hayes, BL Allman - Hearing research, 2013 - Elsevier
In 2006, Turner and colleagues (Behav. Neurosci., 120: 188–195) introduced the gap-startle
paradigm as a high-throughput method for tinnitus screening in rats. Under this paradigm …