Animal models of asthma: utility and limitations

MV Aun, R Bonamichi-Santos… - Journal of asthma …, 2017 - Taylor & Francis
Clinical studies in asthma are not able to clear up all aspects of disease pathophysiology.
Animal models have been developed to better understand these mechanisms and to …

Heaves, an asthma‐like disease of horses

M Leclere, A LAVOIE‐LAMOUREUX, JP LAVOIE - Respirology, 2011 - Wiley Online Library
Animal models have been developed to investigate specific components of asthmatic airway
inflammation, hyper‐responsiveness or remodelling. However, all of these aspects are …

Equine asthma: Integrative biologic relevance of a recently proposed nomenclature

S Bond, R Léguillette, EA Richard… - Journal of veterinary …, 2018 - Wiley Online Library
The term “equine asthma” has been proposed as a unifying descriptor of inflammatory
airway disease (IAD), recurrent airway obstruction (RAO), and summer pasture‐associated …

Asthma “of horses and men”—How can equine heaves help us better understand human asthma immunopathology and its functional consequences?

M Bullone, JP Lavoie - Molecular immunology, 2015 - Elsevier
Animal models have been studied to unravel etiological, immunopathological, and genetic
attributes leading to asthma. However, while experiments in which the disease is artificially …

Pathological roles of neutrophil‐mediated inflammation in asthma and its potential for therapy as a target

H Gao, S Ying, Y Dai - Journal of immunology research, 2017 - Wiley Online Library
Asthma is a chronic inflammatory disease that undermines the airways. It is caused by
dysfunction of various types of cells, as well as cellular components, and is characterized by …

Recurrent airway obstruction: a review

RS Pirie - Equine veterinary journal, 2014 - Wiley Online Library
Recurrent airway obstruction is a widely recognised airway disorder, characterised by
hypersensitivity‐mediated neutrophilic airway inflammation and lower airway obstruction in …

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Y Li, L Zhang, X Wang, W Wu… - Drug Development …, 2019 - Wiley Online Library
Asthma is termed as the induction of chronic inflammation in the airway lumen of lungs due
to accumulation of inflammatory cells which affects normal breathing process. Prolonged …

The role of interleukin‐4 in rheumatic diseases

C Dong, T Fu, J Ji, Z Li, Z Gu - Clinical and experimental …, 2018 - Wiley Online Library
Rheumatism is a group of diseases, most of which are autoimmune diseases, that violate
joints, bones, muscles, blood vessels and related soft tissue. As is well known, cytokines …

Rapid and label-free microfluidic neutrophil purification and phenotyping in diabetes mellitus

HW Hou, C Petchakup, HM Tay, ZY Tam, R Dalan… - Scientific reports, 2016 - nature.com
Advanced management of dysmetabolic syndromes such as diabetes will benefit from a
timely mechanistic insight enabling personalized medicine approaches. Herein, we present …

Markers of systemic inflammation in horses with heaves

A Lavoie‐Lamoureux, M Leclere… - Journal of veterinary …, 2012 - Wiley Online Library
Background Systemic inflammation in horses with heaves is poorly characterized.
Objectives To assess acute phase proteins (APP) and inflammatory cytokine profiles in …