The classification of adenohypophysial neoplasms as “pituitary neuroendocrine
tumors”(PitNETs) was proposed in 2017 to reflect their characteristics as epithelial …

'Pituitary tumours' is an umbrella term for various tumours originating from different regions
of the hypothalamic–pituitary system. The vast majority of pituitary tumours are pituitary …

Objective A somatic mutational hotspot in the SF3B1 gene was reported in lactotroph
tumours. The aim of our study was to examine the prevalence of driver SF3B1 variants in a …

The purpose of this study was to analyze the impact of copy number variations (CNV) on
sporadic pituitary neuroendocrine tumors (PitNETs) prognosis, to identify specific prognosis …

Introduction Germline loss-of-function variants in PAM, encoding peptidylglycine α-
amidating monooxygenase (PAM), were recently discovered to be enriched in conditions of …

Simple Summary Pituitary neuroendocrine tumors are non-cancerous tumors of the pituitary
gland, that may overproduce hormones leading to serious health conditions or due to tumor …

Molecular pathology has advanced our understanding of many tumors and offers
opportunities to identify novel therapies. In the pituitary, the field has uncovered several …

The current treatment paradigm for prolactinomas involves dopamine agonist (DA) therapy
as the first-line treatment, with surgical resection reserved for cases where there is DA failure …

Statement. Nat. Rev. Endocrinol. 19, 722–740 (2023) 1), which highlights rare but serious
dopamine agonist-related toxicities, such as impulse control disorders, as we demonstrated …

OBJECTIVE Innovations in genomics, epigenomics, and transcriptomics now lay the
groundwork for therapeutic interventions against neoplastic disease. In the past 30 years …