Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Designated as an emerging epidemic in 1997, heart failure (HF) remains a major clinical
and public health problem. This review focuses on the most recent studies identified by …

Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated
cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Succinate dehydrogenase, which is known as mitochondrial complex II, has proven to be a
fascinating machinery, attracting renewed and increased interest in its involvement in …

The emergence of human induced pluripotent stem cells (hiPSCs) and efficient
differentiation of hiPSC-derived cardiomyocytes (hiPSC-CMs) induced from diseased …

Impairments in certain cardiac genes confer risk for myocarditis in children. To determine the
extent of this association, we performed genomic sequencing in predominantly adult …

The number of therapies for heart failure (HF) with reduced ejection fraction has nearly
doubled in the past decade. In addition, new therapies for HF caused by hypertrophic and …

Dilated cardiomyopathy is the second most common cause for heart failure with no cure
except a high-risk heart transplantation. Approximately 30% of patients harbor heritable …

Background: Phospholamban (PLN) is a critical regulator of calcium cycling and contractility
in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated …