Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Epidemiological studies suggest that a father's diet can influence offspring health. A
proposed mechanism for paternal transmission of environmental information is via the …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

The epigenetic profile of germ cells, which is defined by modifications of DNA and
chromatin, changes dynamically during their development. Many of the changes are …

Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …

Though there are multiple routes through which parents can influence their offspring, recent
studies of environmentally induced epigenetic variation have highlighted the role of non …

A unique feature of the germ cell lineage is the generation of totipotency. A critical event in
this context is DNA demethylation and the erasure of parental imprints in mouse primordial …

The ability of an environmental exposure to induce an epigenetic transgenerational adult
onset disease phenotype is discussed in the current mini-review in the context of defining …

We have previously described individuals presenting with transient neonatal diabetes and
showing a variable pattern of DNA hypomethylation at imprinted loci throughout the …