Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance

S Mirzaei, AT Mohammadi, MH Gholami… - Pharmacological …, 2021 - Elsevier
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Pathological mechanism and targeted drugs of COPD

P Guo, R Li, TH Piao, CL Wang, XL Wu… - International journal of …, 2022 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis, emphysema,
and small airway obstruction. Incompletely reversible airflow limitation, inflammation …

β‐Sitosterol‐assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line

K Raj R - Journal of biomedical materials research Part A, 2020 - Wiley Online Library
Cancer nanomedicine is an emerging field of cancer therapeutics. Incidence of
hepatocellular carcinoma (HCC) is increasing worldwide, and currently, it is the second …

Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis

JY Kang, MM Xu, Y Sun, ZX Ding, YY Wei… - International …, 2022 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is featured by intensive
inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis …

Reactive oxygen species and antioxidative defense in chronic obstructive pulmonary disease

A Taniguchi, M Tsuge, N Miyahara, H Tsukahara - Antioxidants, 2021 - mdpi.com
The respiratory system is continuously exposed to endogenous and exogenous oxidants.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of …

[HTML][HTML] Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson's disease: A review

Q Wang, BOA Botchway, Y Zhang, X Liu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Parkinson's disease (PD) is a familiar neurodegenerative disease, accompanied by motor
retardation, static tremor, memory decline and dementia. Heredity, environment, age and …

Oxidative stress and antioxidant pathway in allergic rhinitis

M Han, D Lee, SH Lee, TH Kim - Antioxidants, 2021 - mdpi.com
Oxidative stress is the cause and consequence of redox metabolism in various physiological
and pathological conditions. Understanding the molecular pathways underlying oxidative …

Role of NRF2 and Sirtuin activators in COVID-19

H Khan, S Patel, A Majumdar - Clinical Immunology, 2021 - Elsevier
COVID-19 is a pandemic requiring immediate solution for treatment because of its complex
pathophysiology. Exploration of novel targets and thus treatment will be life savers which is …

Alkaloids as natural NRF2 inhibitors: Chemoprevention and cytotoxic action in Cancer

D Gjorgieva Ackova, V Maksimova, K Smilkov… - Pharmaceuticals, 2023 - mdpi.com
Being a controller of cytoprotective actions, inflammation, and mitochondrial function through
participating in the regulation of multiple genes in response to stress-inducing endogenous …

Oxidative stress promotes corticosteroid insensitivity in asthma and COPD

BW Lewis, ML Ford, LK Rogers, RD Britt Jr - Antioxidants, 2021 - mdpi.com
Corticosteroid insensitivity is a key characteristic of patients with severe asthma and COPD.
These individuals experience greater pulmonary oxidative stress and inflammation, which …