Foundations of gastrointestinal-based drug delivery and future developments

JN Chu, G Traverso - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

Large animal models in regenerative medicine and tissue engineering: to do or not to do

I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Swine as models in biomedical research and toxicology testing

MM Swindle, A Makin, AJ Herron… - Veterinary …, 2012 - journals.sagepub.com
Swine are considered to be one of the major animal species used in translational research,
surgical models, and procedural training and are increasingly being used as an alternative …

A comparative anatomic and physiologic overview of the porcine heart

PP Lelovas, NG Kostomitsopoulos… - Journal of the …, 2014 - ingentaconnect.com
Despite advances during the last 2 decades in every aspect of cardiovascular research
(interventional cardiology, cardiopulmonary resuscitation, and so forth), Western societies …

Porcine models of cutaneous wound healing

M Seaton, A Hocking, NS Gibran - ILAR journal, 2015 - academic.oup.com
Cutaneous wound healing in the pig is frequently used as a model for human cutaneous
wound healing. In this review, we examine the appropriateness of this model for studying …

In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API …

E Sjögren, B Abrahamsson, P Augustijns… - European Journal of …, 2014 - Elsevier
This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

Guidelines for animal exercise and training protocols for cardiovascular studies

DC Poole, SW Copp, TD Colburn… - American Journal …, 2020 - journals.physiology.org
Whole body exercise tolerance is the consummate example of integrative physiological
function among the metabolic, neuromuscular, cardiovascular, and respiratory systems …

The utility of the minipig as an animal model in regulatory toxicology

G Bode, P Clausing, F Gervais, J Loegsted… - … of pharmacological and …, 2010 - Elsevier
In this article we review the value and utility of the minipig as an animal model in regulatory
toxicity testing. Our review is based on detailed consideration of the comparative biology of …

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

SJ Gray, S Nagabhushan Kalburgi, TJ McCown… - Gene therapy, 2013 - nature.com
Injection of adeno-associated virus (AAV) into the cerebrospinal fluid (CSF) offers a means
to achieve widespread transgene delivery to the central nervous system, where the doses …

18F-NaF and 18F-FDG as molecular probes in the evaluation of atherosclerosis

ML McKenney-Drake, MC Moghbel, K Paydary… - European journal of …, 2018 - Springer
The early detection of atherosclerotic disease is vital to the effective prevention and
management of life-threatening cardiovascular events such as myocardial infarctions and …