The past decade has witnessed an upsurge in studies demonstrating mitochondrial transfer
as one of the emerging mechanisms through which mesenchymal stem cells (MSCs) can …

Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and
chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue …

Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel housekeeper of
hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs …

Maintenance of mitochondrial function and integrity is critical for normal cell survival,
particularly in non-dividing cells with a high-energy demand such as cardiomyocytes. Well …

Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

Mitochondrial quality is a crucial determinant of cell viability, and mitochondrial autophagy
plays a central role in this control mechanism. Based on studies in yeast, numerous …

The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human
biology. However, when ROS generation exceeds endogenous antioxidant capacity …

The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major
aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive …

Resveratrol is a natural polyphenol found in various plants. It has been widely studied on
cardiovascular disorders. It is known that resveratrol can activate Sirtuin proteins and …