RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …

BACKGROUND Ribosomopathies are a heterogeneous group of human disorders that are
in some cases known, and in other cases suspected, to result from ribosome dysfunction …

Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …

Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal …

Regulation of protein turnover allows cells to react to their environment and maintain
homeostasis. Proteins can show different turnover rates in different tissue, but little is known …

Cells typically respond quickly to stress, altering their metabolism to compensate. In
mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis …

The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …