Our sense of hearing enables the processing of stimuli that differ in sound pressure by more
than six orders of magnitude. How to process a wide range of stimulus intensities with …

Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to
affect auditory neural processing and hearing acuity in subjects with normal audiometric …

Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses
require otoferlin. Deafness DFNB 9, caused by mutations in the OTOF gene encoding …

BACKGROUND One hundred years ago, experiments on beating frog hearts identified
acetylcholine (ACh) as the seminal neurotransmitter. Sixty years later, fractionation of the eel …

Brainstem olivocochlear neurons (OCNs) modulate the earliest stages of auditory
processing through feedback projections to the cochlea and have been shown to influence …

The role of the mammalian auditory olivocochlear efferent system in hearing has long been
the subject of debate. Its ability to protect against damaging noise exposure is clear, but …

Alterations of the speech signal, including additive noise and nonlinear distortion, can
reduce speech intelligibility and quality. Hearing aids present an especially complicated …

The mammalian cochlea is innervated by two cholinergic feedback systems called the
medial olivocochlear (MOC) and lateral olivocochlear (LOC) pathways, which send control …

Recent studies reveal great diversity in the structure, function, and efferent innervation of
afferent synaptic connections between the cochlear inner hair cells (IHCs) and spiral …

Key points Age‐related hearing loss (ARHL) is a very heterogeneous disease, resulting from
cellular senescence, genetic predisposition and environmental factors (eg noise exposure) …