Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

Early detection and diagnosis of many cancers is very challenging. Late stage detection of a
cancer always leads to high mortality rates. It is imperative to develop novel and more …

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of
copper and copper triggered cell death in the pathogenesis of cancers have attracted …

Selenium is an essential trace element that is crucial for cellular antioxidant defense against
reactive oxygen species (ROS). Recently, many selenium-containing compounds have …

Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in
maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to …

Clinical efficacy of oxaliplatin is frequently limited by severe adverse effects and therapy
resistance. Acquired insensitivity to oxaliplatin is, at least in part, associated with elevated …

Ferroptosis, characterized by the accumulation of reactive oxygen species and lipid
peroxides, has emerged as an attractive strategy to reverse drug resistance. Of particular …

The intracellular redox homeostasis is a dynamic balancing system between the levels of
free radical species and antioxidant enzymes and small molecules at the core of cellular …

Owing to the unique DNA damaging cytotoxicity, platinum (Pt)-based chemotherapy has
long been the first-line choice for clinical oncology. Unfortunately, Pt drugs are restricted by …

In this article, ligand IPP (IPP= 4-(1H-imidazo [4, 5-f][1, 10] phenanthrolin-2-yl)-N, N-
diphenylaniline) and its three Ru (II) complexes:[Ru (bpy) 2 (IPP)](ClO 4) 2 (1)(bpy= 2, 2 …