Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …

MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling in mitochondria,
peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of …

Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Due to the intrinsic weak immunogenicity of tumor cells and the quantitatively and
functionally different populations of immune cells, immunosuppression has become the …

Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …

Background Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to
ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to …

The incidence of pancreatic cancer is increasing worldwide. The most common form is
represented by pancreatic ductal adenocarcinoma (PDAC) which has been shown to be …

Intracellular DNA sensors regulate innate immunity and can provide a bridge to adaptive
immunogenicity. However, the activation of the sensors in antigen-presenting cells (APCs) …