Introduction: The rising prevalence of obesity confronts clinicians with dosing problems in
the (extreme) overweight population. Obesity has a great impact on key organs that play a …

Patient groups prone to polypharmacy and special subpopulations are susceptible to
suboptimal treatment. Refined dosing in special populations is imperative to improve …

Introduction: Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Introduction Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

Obesity and morbid obesity are associated with many physiological changes affecting
pharmacokinetics, such as increased blood volume, cardiac output, splanchnic blood flow …

Bariatric or weight‐loss surgery is a popular option for weight reduction. Depending on the
surgical procedure, gastric changes like decreased transit time and volume and increased …

Concerns over maternal and fetal drug exposures highlight the need for a better
understanding of drug distribution into the fetus through the placental barrier. This study …

Background and purpose—Obesity increases the risk of deep infection after total joint
arthroplasty (TJA). Our objective was to determine whether there may be body mass index …

Over the last few decades, scientists and clinicians have often focused their attention on the
unbound fraction of drugs as an indicator of efficacy and the eventual outcome of drug …