Objectives The objective of this study was to describe the population pharmacokinetics of
cefazolin in plasma and the interstitial fluid of subcutaneous tissue of post-trauma critically ill …

Introduction Obesity is associated with many pathophysiological changes that may result in
altered drug metabolism. The aim of this study is to investigate the influence of obesity on …

Currently, there is no consensus on whether a standard 2-g prophylactic cefazolin dose
provides sufficient antimicrobial coverage in obese surgical patients. This systematic review …

Abstract Background and Objective Ciprofloxacin is a fluoroquinolone used for empirical
and targeted therapy of a wide range of infections. Despite the increase in obesity …

The majority of marketed drugs remain understudied in some patient populations such as
pregnant women, paediatrics, the obese, the critically-ill, and the elderly. As a consequence …

Guidelines for surgical prophylactic dosing of cefazolin in bariatric surgery vary in terms of
recommended dose. This study aimed to describe the plasma and interstitial fluid (ISF) …

Surgical site infection (SSI) following caesarean section is common, resulting in significant
morbidity. Several factors are known to contribute to wound infection, including maternal …

Purpose While many guidelines recommend higher doses of cefazolin for patients with
higher body weights, there are scant outcome data showing the benefit of higher doses …

Traditionally, there have been uniform antibiotic dosing guidelines for prophylaxis for clean–
clean-contaminated surgery in both non-obese and obese adults. All other factors …

Background: This controlled clinical study aimed to investigate the impact of obesity on
plasma and tissue pharmacokinetics of meropenem. Methods: Obese (body mass index …