Purpose To determine the efficacious cefazolin prophylactic dose for bariatric surgery using
free subcutaneous concentrations accessed by microdialysis after 2 g or 3 g iv bolus dosing …

Background Despite the increasing numbers of obese patients undergoing elective surgery,
there is a lack of evidence-based dosing guidelines for peri-operative medications in …

Abstract Background and Objective The interstitial fluid of tissues is the effect site for
antibiotics targeting extracellular pathogens. Microdialysis studies investigating these …

Morbid obesity is known to increase the risk of surgical site infections. Optimal
concentrations of prophylactic antibacterial drugs are required. Using Monte Carlo …

Background In obese patients undergoing sleeve gastrectomy, the blood and fatty-tissue
concentrations of cefazolin required for adequate antibiotic prophylaxis are uncertain …

Individuals with obesity are at increased risk of developing infectious diseases. Timely
administration of an effective dose of an antimicrobial agent is paramount to safeguard …

Background: Periprosthetic joint infections (PJI) following joint arthroplasty are now the
leading cause of reoperation and are associated with serious morbidity to the patient, often …

Obesity, which is defined as having a body mass index of 30 kg/m2 or greater, has been
recognized as a serious health problem that increases the risk of many comorbidities (eg …

Adequate drug penetration to a site of infection is absolutely imperative to ensure sufficient
antimicrobial treatment. Microdialysis is a minimally invasive, versatile technique, which can …

French and American guidelines recommend increased dosage regimens of cefazolin (CFZ)
for surgical prophylaxis in patients with a body mass index (BMI)≥ 35 kg/m 2 or with a total …