Concentrations in the interstitial tissue space are of clinical interest for many antibiotics and
can be directly measured by microdialysis. Quantitative microdialysis strongly depends on …

OBJECTIVE Despite a general consensus regarding the administration of preoperative
antibiotics, poorly defined comparison groups and underpowered studies prevent clear …

The aim of this study was to explore the utility of target‐concentration controlled infusion
(TCI) as a prophylactic antibiotic administration method based on the results of a population …

The tissue distribution and percutaneous drug absorption of indomethacin (IND) patches
were studied using commercial IND as a comparison. The concentration of IND in skin …

Editorials 902 www. pccmjournal. org September 2017• Volume 18• Number 9 prospective
studies of renally excreted drugs in which target concentrations are met in the majority of …

Purpose Antibiotic dosing in obese surgical patients has not been adequately evaluated.
The objective of this study was to identify whether currently prescribed doses of cefoxitin …

Background Paddle lead spinal cord stimulation (SCS) is used to treat refractory chronic
pain. Morbidly obese patients seek SCS to reduce chronic pain. However, these patients …

Introduction Cefazolin is the leading antibiotic used to prevent surgical site infections
worldwide. Consensus guidelines recommend adjustment of the cefazolin dose above and …

The optimal perioperative duration for the administration of cefazolin and other prophylactic
antibiotics remains unclear. This study aimed to describe the pharmacodynamics of …

Clinicians are increasingly faced with challenges regarding the pharmacological treatment
of obese pediatric patients. To provide guidance for these treatments, a better understanding …