Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment?

Q Xie, R Liu, J Jiang, J Peng, C Yang, W Zhang… - Stem cell research & …, 2020 - Springer
Background Human umbilical cord mesenchymal stem cells (HUC-MSCs) present in the
umbilical cord tissue are self-renewing and multipotent. They can renew themselves …

Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer's disease

M Guo, Z Yin, F Chen, P Lei - Alzheimer's Research & Therapy, 2020 - Springer
Alzheimer's disease (AD) has been a devastating public health with the development of
global aging. Approaches for reducing the current AD epidemic are becoming a primary …

Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers

N Kučuk, M Primožič, Ž Knez, M Leitgeb - International journal of …, 2021 - mdpi.com
Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety
of therapeutic applications due to their unique characteristics, especially due to the …

Pharmacokinetics and biodistribution of extracellular vesicles administered intravenously and intranasally to Macaca nemestrina

T Driedonks, L Jiang, B Carlson, Z Han… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) have potential in disease treatment since they can be loaded
with therapeutic molecules and engineered for retention by specific tissues. However …

Preterm brain injury, antenatal triggers, and therapeutics: timing is key

DRMG Ophelders, R Gussenhoven, L Klein… - Cells, 2020 - mdpi.com
With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential

J Cai, J Wu, J Wang, Y Li, X Hu, S Luo, D Xiang - Cell & bioscience, 2020 - Springer
Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy.
However, the risk of immune rejection associated with cell transplant therapy hampers its …

Intranasal delivery of mesenchymal stem cells-derived extracellular vesicles for the treatment of neurological diseases

S Herman, I Fishel, D Offen - Stem Cells, 2021 - academic.oup.com
Neurological disorders are diseases of the central nervous system (CNS), characterized by
a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem …

Extracellular vesicles and intercellular communication in the central nervous system

LR Lizarraga‐Valderrama, GK Sheridan - FEBS letters, 2021 - Wiley Online Library
Neurons and glial cells of the central nervous system (CNS) release extracellular vesicles
(EVs) to the interstitial fluid of the brain and spinal cord parenchyma. EVs contain proteins …

Exosomes as CNS drug delivery tools and their applications

K Sun, X Zheng, H Jin, F Yu, W Zhao - Pharmaceutics, 2022 - mdpi.com
Central nervous system (CNS) diseases threaten the health of people all over the world.
However, due to the structural and functional particularities of the brain and spinal cord …