Epigenetic drug discovery field has evidenced significant advancement in the recent times.
A plethora of small molecule inhibitors have progressed to clinical stage investigations and …

As the central organ of stress and adaptation to stressors, the brain plays a pivotal role in
behavioral and physiological responses that may lead to successful adaptation or to …

De novo transcription of DNA is a fundamental requirement for the formation of long-term
memory. It is required during both consolidation and reconsolidation, the posttraining and …

Turnover and exchange of nucleosomal histones and their variants, a process long believed
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe a …

Major depressive disorder is a chronic, remitting syndrome involving widely distributed
circuits in the brain. Stable alterations in gene expression that contribute to structural and …

Epigenetics is a burgeoning area of biomedical research into the mechanisms by which
genes are regulated—how the activity of producing proteins is controlled. Although …

Cells of a multicellular organism, all containing nearly identical genetic information, respond
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Parkinson's disease (PD) is the most common movement disorder affecting more than 4
million people worldwide. The primary motor symptoms of the disease are due to …

Epigenetic mechanisms govern the transcription of the genome. Research with model
systems reveals that environmental conditions can directly influence epigenetic mechanisms …