The blood–brain barrier (BBB) is a dynamic platform for exchange of substances between
the blood and the brain parenchyma, and it is an essential functional gatekeeper for the …

High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Background Rhodiola crenulate (R. crenulate), a famous Tibetan medicine, has been
demonstrated to possess superiorly protective effects in high-altitude hypoxic brain injury …

High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Ethnopharmacological relevance Rhodiola crenulata, a traditional Tibetan medicine, has
shown promise in the treatment of hypobaric hypoxia (HH)-induced brain injury. However …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …

Salidroside (Sal), an active ingredient from Rhodiola crenulate, has been reported to exert
neuroprotection in cerebral injury from hypobaric hypoxia (HH) at high altitude. However, it …

Various strategies can be employed to prevent and manage altitude illnesses, including
habituation, oxygenation, nutritional support, and medication. Nevertheless, the utilization of …

Areas at high-altitude, annually attract millions of tourists, skiers, trekkers, and climbers. If not
adequately prepared and not considering certain ascent rules, a considerable proportion of …

The need to protect neural tissue from toxins or other substances is as old as neural tissue
itself. Early recognition of this need has led to more than a century of investigation of the …