Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

Sensorineural hearing impairment is the most common sensory disorder and a major health
and socio-economic issue in industrialized countries. It is primarily due to the degeneration …

The use of viral vectors for inner ear gene therapy is receiving increased attention for
treatment of genetic hearing disorders. Most animal studies to date have injected viral …

The capacity of adult mammals to regenerate sensory hair cells is not well defined. To
explore early steps in this process, we examined reactivation of a transiently expressed …

Research in the genetics of hearing and deafness has evolved rapidly over the past years,
providing the molecular foundation for different aspects of the mechanism of hearing …

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

The cochlear implant is the most successful bionic prosthesis and has transformed the lives
of people with profound hearing loss. However, the performance of the “bionic ear” is still …

An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …

Amazing progress has been made in providing useful hearing to hearing-impaired
individuals using cochlear implants, but challenges remain. One such challenge is …

Highlights•Modern neurotrophin delivery systems should be able to cure neuronal
loss.•Gene carriers deliver stable neurotrophic proteins to specific brain regions.•Delivery …