Bench to bedside—new insights into the pathogenesis of necrotizing enterocolitis

DJ Hackam, CP Sodhi - Nature reviews Gastroenterology & hepatology, 2022 - nature.com
Necrotizing enterocolitis (NEC) is the leading cause of death and disability from
gastrointestinal disease in premature infants. Recent discoveries have shed light on a …

[HTML][HTML] The double-edged functions of necroptosis

K Ye, Z Chen, Y Xu - Cell Death & Disease, 2023 - nature.com
Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

[HTML][HTML] The Paneth cell: the curator and defender of the immature small intestine

SR Lueschow, SJ McElroy - Frontiers in immunology, 2020 - frontiersin.org
Paneth cells were first described in the late 19th century by Gustav Schwalbe and Josef
Paneth as columnar epithelial cells possessing prominent eosinophilic granules in their …

Necrotizing enterocolitis, gut microbes, and sepsis

JW Duess, ME Sampah, CM Lopez, K Tsuboi… - Gut …, 2023 - Taylor & Francis
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants and the
leading cause of death and disability from gastrointestinal disease in this vulnerable …

Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

ML Kovler, AJ Gonzalez Salazar, WB Fulton… - Science translational …, 2021 - science.org
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, whose
pathogenesis remains incompletely understood, although activation of the Gram-negative …

[HTML][HTML] Multifunctional benefits of prevalent HMOs: Implications for infant health

DR Hill, JM Chow, RH Buck - Nutrients, 2021 - mdpi.com
Breastfeeding is the best source of nutrition during infancy and is associated with a broad
range of health benefits. However, there remains a significant and persistent need for …

[HTML][HTML] Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis

P Lu, Y Yamaguchi, WB Fulton, S Wang, Q Zhou… - Nature …, 2021 - nature.com
Necrotizing enterocolitis (NEC) is a disease of premature infants characterized by acute
intestinal necrosis. Current dogma suggests that NEC develops in response to post-natal …

The role of necroptosis in disease and treatment

X Liu, X Xie, Y Ren, Z Shao, N Zhang, L Li, X Ding… - MedComm, 2021 - Wiley Online Library
Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis,
triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1) …

[HTML][HTML] Necroptosis in intestinal inflammation and cancer: new concepts and therapeutic perspectives

A Negroni, E Colantoni, S Cucchiara, L Stronati - Biomolecules, 2020 - mdpi.com
Necroptosis is a caspases-independent programmed cell death displaying intermediate
features between necrosis and apoptosis. Albeit some physiological roles during embryonic …

Impact of dietary fibers in infant formulas on gut microbiota and the intestinal immune barrier

C Kong, MM Faas, P de Vos, R Akkerman - Food & function, 2020 - pubs.rsc.org
Human milk (HM) is the gold standard for the nutrition of infants. An important component of
HM is human milk oligosaccharides (hMOs), which play an important role in gut microbiota …